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KMID : 0869619980150010053
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Journal of Korean Society of Hospital Pharmacists
1998 Volume.15 No. 1 p.53 ~ p.56
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Correlation of Vancomycin and Amikacin Pharmacokinetic Parameters in Neonates
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정현주/Chung, Hyun Ju
조영미/신성경/신혜영/노환성/Cho, Young mi/Shin, Sung kyoung/Shin, Hae young/Ro, Hwan Seong
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Abstract
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In the case of infection in hospital or sepsis by MRSA in neonates, vancomycin is the drug of choice. If the symptoms of infection get worse and infection by G(-) is suspected, amikacin is added to vancomycin. If these two drugs excreted through kidney are combined, the incidence of nephrotoxicity and ototoxicity become more often. Therefore the TDM must be carried out more strictly, but the guideline in neonate is not established for their variability of pharmacokinetic parameters. In this report, we are to establish the guideline we could use when amikacin is added to vancomycin to neonates in infectious state or sepsis for MRSA by use of pharmacokinetic parameters when vancomycin and amikacin used for combine therapy in neonates in NICU
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